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Perinatal Mental Health
A Comparative cross-sectional study on maternal mental health and infant bonding among pregnant and parenting Adolescent Girls and Young Women Major Goals: To understand the prevalence, risk factors and consequences of maternal mental health in pregnant and parenting AGYW in low-resource settings in Kenya and the impact of maternal mental health problems on mother-infant bonding and parenting practices Started on
HPV Self Sampling Study
Evaluation of Uptake and Acceptability of Self-Sampling for HPV Testing Among Women in Kisumu, Kenya Major goal: To evaluate the uptake, acceptability and feasibility of self-sampling for high-risk-HPV DNA in family planning services combined with digital delivery of results and linkage to care via test in resource-limited settings Started in October 2022, 256 participants enrolled from Kisumu County Referral and
Tunawiri Study
Integration of a collaborative care model for perinatal mental health and HIV in Kenya. The overall objective of this study is to integrate a collaborative care model (CCM) for perinatal CMD within routine antenatal HIV services in Kenya by systematically introducing CCM to ANC/HIV clinics already serving PPWH with probable depression or anxiety. We will recruit approximately 900 pregnant and
Solidarity Trial Vaccine Study
An international randomized trial of candidate vaccines against COVID-19 Major Goals: The major goal of this project is to evaluate the effect of novel vaccines on the rate of virologically confirmed COVID-19 disease, regardless of severity Started in January 2023 501 participants were enrolled from Kisumu county and environs (Follow-up of the participants is ongoing) Funded by WHO/KAVI/UON
SANOFI Covid Vaccine Study
A parallel-group, Phase III, multi-stage, modified double-blind, multi-armed study to assess the efficacy, safety, and immunogenicity of two SARS-CoV-2 Adjuvanted Recombinant Protein Vaccines (monovalent and bivalent) for prevention against COVID-19 in adults 18 years of age and older. The major goals of this project are to assess the efficacy, safety, and immunogenicity of two CoV2 preS dTM-AS03 vaccines (monovalent and
Concept-PrEP
Evaluation of a Digital Health Intervention ( ConceptPrEP-on-demand ) among adolescent girls and young women in Kisumu, Kenya. The major goal of this project is to evaluate, and refine a digital health service model (Concept PrEP-on-demand ) co-designed with AGYW that is feasible and sustainable in resource-limited settings Started in November 2022, 206 participants enrolled from Kisumu region Funded by
Echo-HPV Study
Evaluation of HPV burden among young women in Africa: a follow-on study to the ECHO Trial Major Goals: The major goals of this project are to address whether specific contraceptives influence HPV prevalence in women initiating use of the standard Cu-IUD, the LNG implant, or injectable DMPA. Started in June 2022, 84 participants were enrolled; Analysis currently ongoing Funded by
TATUA Study
•Adapting a lay health worker problem-solving therapy intervention for at-risk pregnant/postpartum women with HIV in Kenya to promote treatment success The major goal of this project is to determine whether risk stratification of PWLWH in conjunction with a tailored psychosocial support intervention can optimize health outcomes for women and infants by preventing HIV treatment failure and disengagement from care. Started
